Abstract Search

ea0031se1.5 | (1) | SFEBES2013

Type 1 and type 2 diabetes are the same disorder of insulin resistance, but with different genetic backgrounds

Some 40 years ago, diabetes was re-classified from a single disorder into autoimmune (T1D) and metabolic (T2D) on the interpretation of observation rather than the outcome of experiment. The 20 or so experiments carried out since to test the autoimmune hypothesis (largely randomised trials of immunotherapy) have proved disappointing, and none has translated into patient benefit. There is arguably reason to question the autoimmunity paradigm. The accelerator hypothesis argues t...

0 shares

ea0015oc1 | Young Endocrinologist prize session | SFEBES2008

Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B gene mutation carriers

Srirangalingam Umasuthan , Walker Lisa , Khoo Bernard , MacDonald Fiona , Gardner Daphne , Wilkin Terence J , Skelly Robert H , George Emad , Spooner David , Monson John P , Grossman Ashley B , Akker Scott A , Pollard Patrick J , Plowman Nick , Avril Norbert , Berney Dan M , Burrin Jacky M , Reznek Rodney , Ajith Kumar VK , Maher Eamonn R , Chew Shern L

Background: Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase (SDH) gene mutations.Objective: To describe the clinical manifestations of subjects with SDH-B gene mutations.Design: Retrospective case series.Patients: Thirty-two subjects with SDH-B gene mutations followed-up between 1975 and 2007. Mean follow-up of 5.8 years (S.D....

0 shares

Endocrine Abstracts

Type 1 and type 2 diabetes are the same disorder of insulin resistance, but with different genetic backgrounds

Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B gene mutation carriers

BiosciAbstracts